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11 -- A controversial drug called Avandia, used by millions of diabetics to control blood sugar, greatly increases their risk of heart attack and heart failure, researchers report. Three other studies (mean duration 41 months; 14,067 total patients), comparing Avandia to some other approved oral antidiabetic agents or placebo, have not confirmed or excluded this risk. Furthermore, discontinuation or dose reduction of Avandia must be considered. While on Avandia, I was unable to complete stress tests. The FDA has requested that Avandia's maker, GlaxoSmithKline, strengthen its warning about heart-failure risk. "Across the extensive dataset for Avandia, GlaxoSmithKline believes there is no consistent or systematic evidence that Avandia increases the risk of heart attack or cardiovascular death in comparison to other anti-diabetic medicines," the company said in a prepared statement.

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